Grand Cevahir Hotel is situated just 5 km away from the business hubs of Levent and Maslak, 3 km away from the popular entertainment and shopping districts of Taksim and Nişantaşı, and 3 km away from the Lütfi Kırdar Convention Centre and Cemal Reşit Rey Concert Hall. It is located just 1 km away from Istanbul Cevahir Shopping Mall, the second largest shopping centre in Europe.

It is located 9 km away from the historic peninsula, home to the Grand Bazaar, Hagia Sophia Museum, Topkapi Palace, and the Spice Bazaar; 35 km (28 minutes) away from Istanbul International Airport; and 42 km away from Sabiha Gökçen International Airport.